Colorful Activity: Nerve Cells in the Hippocampus
Published: 10.05.2012
This image shows a tangle of nerve cells in the Hippocampus. The excitatory neurons glow green. Those colored red have an inhibitory effect on the neuronal discharge pattern due to the Neurotransmitter GABA. However, the blue nerve cells are of particular interest to researchers. They indicate that Gene transfer has been successful: the neurons produce a blue-glowing recombinant fluorescent protein.
You can find more information and exciting images on this topic in our slideshow ▸ Communication under the microscope.
© Jochen Meier /MDC Berlin, 2010
The hippocampus is the largest part of the Archicortex and an area in the Temporal lobe It is also an important part of the Limbic system Functionally, it is involved in Memory processes, but also in spatial orientation and learning. It comprises the subiculum, the dentate gyrus, and the Ammon's horn with its four fields CA1-CA4.
Changes in the structure of the hippocampus due to stress are associated with chronic pain. The hippocampus also plays an important role in the amplification of pain through anxiety.
Exciting synapses are described as excitatory when they depolarize the subsequent cell membrane and can thus lead to the formation of an Action potential An excitatory effect is usually produced by an exciting transmitter (messenger substance), such as Glutamate. The opposite is an inhibitory synapse.
A neurotransmitter is a chemical messenger, an intermediary substance. It is released by the sender Neuron at the sites of cell-cell communication and has an excitatory or inhibitory effect on the receiver neuron.
GABA is an amino acid and the most important inhibitory neurotransmitter, which acts as a messenger in the transmission of information between neurons at their synapses.
Information unit on DNA. Specialized enzymes translate the core component of a gene into ribonucleic acid (RNA). While some ribonucleic acids perform important functions in the cell themselves, others specify the order in which the cell should assemble individual amino acids into a specific protein. The gene thus provides the code for this protein. In addition, a gene also includes regulatory elements on the DNA that ensure that the gene is read exactly when the cell or organism actually needs its product.
Hippocampus
The hippocampus is the largest part of the archicortex and an area in the temporal lobe. It is also an important part of the limbic system. Functionally, it is involved in memory processes, but also in spatial orientation and learning. It comprises the subiculum, the dentate gyrus, and the Ammon's horn with its four fields CA1-CA4.
Changes in the structure of the hippocampus due to stress are associated with chronic pain. The hippocampus also plays an important role in the amplification of pain through anxiety.
Archicortex
An ancient structure of the cerebrum in terms of evolutionary development, which, in contrast to the isocortex (also called the neocortex), has a three-layer structure. The archicortex mainly comprises the hippocampal structures.
Temporal lobe
Lobus temporalis
The temporal lobe is one of the four lobes of the cerebrum and is located laterally (on the side) at the bottom. It contains important areas such as the auditory cortex and parts of Wernicke's area, as well as areas for higher visual processing; deep within it lies the medial temporal lobe with structures such as the hippocampus.
Limbic system
The limbic system is a functional unit in the brain. It consists of interconnected structures, primarily in the cerebrum and diencephalon. The structures assigned to the system vary depending on the source, but the most important components are the hippocampus, amygdala, cingulate gyrus, septum, and mammillary bodies. The limbic system is involved in autonomic and visceral processes as well as in mechanisms of emotion, memory, and learning. Some authors mistakenly reduce the limbic system to the emotional world by referring to it as the "emotional brain."
Memory
Memory is a generic term for all types of information storage in the organism. In addition to pure retention, this also includes the absorption of information, its organization, and retrieval.
Ammon's horn
cornu ammonis
Part of the cerebrum, specifically the front end of the hippocampus. The Cornu Ammonis is divided into fields CA1 to CA4. It owes its name to its shape, which resembles the horn of an ammon sheep.
excitatory
Exciting synapses are described as excitatory when they depolarize the subsequent cell membrane and can thus lead to the formation of an action potential. An excitatory effect is usually produced by an exciting transmitter (messenger substance), such as glutamate. The opposite is an inhibitory synapse.
Action potential
In excitable cells (e.g., neurons or muscle cells), very rapid changes in electrical potential occur across the cell membrane. This event is the basis for signal conduction along the axon of the nerve cell. The action potential continues along the cell membrane and, according to the all-or-nothing principle, only occurs when the cell has been sufficiently excited.
Glutamate
Glutamate is an amino acid and the most important excitatory neurotransmitter, which acts as a messenger substance in the transmission of information between neurons at their synapses.
Synapse
A synapse is a connection between two neurons and serves as a means of communication between them. It consists of a presynaptic region – the terminal button of the sender neuron – and a postsynaptic region – the region of the receiver neuron with its receptors. Between them lies the synaptic cleft.
Neurotransmitter
A neurotransmitter is a chemical messenger, an intermediary substance. It is released by the sender neuron at the sites of cell-cell communication and has an excitatory or inhibitory effect on the receiver neuron.
Neuron
A neuron is a specialized cell in the nervous system that is responsible for processing and transmitting information. It receives signals via its dendrites and transmits them via its axon. Transmission occurs electrically within the neuron and, between neurons, usually chemically via synapses.
GABA
GABA is an amino acid and the most important inhibitory neurotransmitter, which acts as a messenger in the transmission of information between neurons at their synapses.
Gene
Information unit on DNA. Specialized enzymes translate the core component of a gene into ribonucleic acid (RNA). While some ribonucleic acids perform important functions in the cell themselves, others specify the order in which the cell should assemble individual amino acids into a specific protein. The gene thus provides the code for this protein. In addition, a gene also includes regulatory elements on the DNA that ensure that the gene is read exactly when the cell or organism actually needs its product.
