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1. Glossary

Secretases

Secretases are proteases that cleave proteins into smaller fragments, often membrane-bound in the case of transmembrane proteins. Cleavage produces intracellular fragments that can act as signals and extracellular fragments that are released into the environment. Some proteins, such as the amyloid precursor protein (APP), offer different cleavage sites for different secretases. Beta-amyloid, the main component of senile plaques, is formed when APP is first cleaved by β-secretase outside the membrane and then by γ-secretase inside the membrane.

1. Krankheiten
2. Alzheimer's disease

How the plaques typical of Alzheimer's disease develop

Two cuts are necessary for the protein APP to form beta-amyloid.

23.09.2013

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Glossar

15.03.2017