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- Glossary
Ampakine
A group of active substances that belong to the "neuroenhancers" and can improve cognitive performance. Among other things, they increase attention span, promote memory, and facilitate learning processes. Their effect is based on binding to AMPA receptors in the brain, which facilitates synaptic transmission at glutamatergic synapses and enhances overall neuronal signal transmission.
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- Glossary
Anterograde amnesia
A form of memory disorder in which the formation of new memories – i.e., the storage of new information – is no longer possible from the time of the damage. Memories from before that time can still be recalled. Those affected usually also forget their forgetfulness.
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- Glossary
Cingulate cortex
A component of the prefrontal cortex located at the front of the brain. Like half a doughnut, the cingulate cortex wraps around the corpus callosum. Functionally, it belongs to the limbic system and is involved in emotion, memory, and motor function.
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- Glossary
Frontotemporal dementia
Frontotemporal dementia is a neurodegenerative disease. Unlike Alzheimer's dementia, Pick's disease usually begins before the age of 60 and initially manifests itself through changes in personality and social behavior. There are also variants that begin with speech disorders. In advanced stages, memory performance is also impaired. The physiological cause is degeneration of nerve cells in the frontal and temporal lobes of the brain. Similar to Alzheimer's disease, the aggregation of certain proteins appears to play a role in pathogenesis. However, doctors do not yet understand exactly what happens in this process and what other factors contribute to the development of Pick's disease. Today, classic Pick's disease is only a subtype of FTD in which characteristic Pick bodies can be detected in the brain.
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- Glossary
Cingulate gyrus
The cingulate gyrus is an important part of the limbic system in the cerebrum. This strip of cortex runs medially in the cerebrum, directly above the corpus callosum. Among other things, it is involved in emotions and memory. Through its connections to limbic and autonomic centers, it can also influence autonomic responses (e.g., heart rate, blood pressure). The anterior (front) region in particular is also associated with attention, motivation, error monitoring, and emotion regulation.
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- Glossary
Parahippocampal gyrus
The parahippocampal gyrus runs along the hippocampus in the lower, inner temporal lobe. Its anterior part is covered by the entorhinal cortex. It is connected to numerous areas of the cerebral cortex and projects to the hippocampus, which it also acts as a gateway to. This means that it is involved in the consolidation of explicit memory content, among other things. In addition, the posterior part of the parahippocampal gyrus contains the parahippocampal place area (PPA), which responds particularly to complex visual scenes such as rooms, landscapes, or streets and thus plays an important role in spatial orientation and location recognition.
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- Glossary
Hebbian theory
Hebbian theory is the hypothesis postulated in 1949 by Canadian psychologist Donald Hebb that the synaptic connection between two neurons is strengthened when both are active at the same time. This principle forms a cellular basis for learning and memory. "Neurons that fire together, wire together" – they form a common connection.
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- Glossary
Hippocampus
The hippocampus is the largest part of the archicortex and an area in the temporal lobe. It is also an important part of the limbic system. Functionally, it is involved in memory processes, but also in spatial orientation and learning. It comprises the subiculum, the dentate gyrus, and the Ammon's horn with its four fields CA1-CA4. Changes in the structure of the hippocampus due to stress are associated with chronic pain. The hippocampus also plays an important role in the amplification of pain through anxiety.
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- Glossary
Savant syndrome
Savant syndrome is a rare phenomenon in which people with cognitive deficits in one or more very limited areas possess astonishing abilities – for example, reciting six-digit prime numbers or drawing a city correctly from memory in detail after flying over it. Probably the best-known savant was Kim Peek, the inspiration for the film Rain Man.
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- Glossary
Confabulation
Confabulation refers to a memory or explanation that the person concerned is completely convinced is true, but which is objectively false. There is no conscious intent to deceive behind this. The cause is usually medical, such as damage to the orbitofrontal or other frontal brain areas, amnestic syndrome (e.g., Korsakoff's syndrome), traumatic brain injury, or dementia.
