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- Glossary
Beta-amyloid
A peptide consisting of 36 to 42 amino acids that is considered the main component of senile plaques and is believed to be responsible for the development of Alzheimer's disease. The starting product is the amyloid precursor protein (APP). Certain enzymes in the cell membrane cut the precursor protein into peptides of various sizes. Amyloids consisting of 40 and 42 amino acids are found in senile plaques, with the 42-amino-acid product forming aggregates particularly quickly, at least in the Petri dish. The normal function of beta-amyloid has not yet been conclusively clarified.
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- Glossary
Oligomer
Chemists define an oligomer as a molecule composed of several structurally similar or identical units. Typically, an oligomer consists of a few monomers (e.g., 2–10, occasionally up to about 30). An example from biochemistry is collagen, which is composed of three identical polypeptide chains and occurs as a trimeric protein in connective tissue. If the number of building blocks significantly exceeds this range, as is the case with DNA, it is referred to as a polymer. Oligomers of beta-amyloid may play an important role in the development of Alzheimer's disease.
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