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1. Glossary

Dorsolateral PFC

The dorsolateral prefrontal cortex is the upper (dorsal) and lateral part of the frontal lobe. It is involved in the planning and regulation of complex motor and intellectual actions. According to one experiment, this also seems to include lying. The dorsolateral PFC regulates these and other abilities in coordination with many other areas of the brain with which it is closely linked.

1. Glossary

Fissure

The strong folding of the cortex (cerebral cortex) creates fissures – from the Latin: cleft. These clefts can be used to describe individual brain structures. For example, the fissura sylvii separates the temporal lobe from the frontal lobe. Less deep clefts are often referred to as sulci. 

1. Glossary

Frontotemporal dementia

Frontotemporal dementia is a neurodegenerative disease. Unlike Alzheimer's dementia, Pick's disease usually begins before the age of 60 and initially manifests itself through changes in personality and social behavior. There are also variants that begin with speech disorders. In advanced stages, memory performance is also impaired. The physiological cause is degeneration of nerve cells in the frontal and temporal lobes of the brain. Similar to Alzheimer's disease, the aggregation of certain proteins appears to play a role in pathogenesis. However, doctors do not yet understand exactly what happens in this process and what other factors contribute to the development of Pick's disease. Today, classic Pick's disease is only a subtype of FTD in which characteristic Pick bodies can be detected in the brain.

1. Glossary

Cerebrum

The cerebrum comprises the cerebral cortex (gray matter), the nerve fibers (white matter), and the basal ganglia. It is the largest part of the brain. The cortex can be divided into four cortical areas: the temporal lobe, frontal lobe, occipital lobe, and parietal lobe.Its functions include the coordination of perception, motivation, learning, and thinking.

1. Glossary

Insula

The insula is a recessed part of the cortex (cerebral cortex) that is covered by the frontal, temporal, and parietal lobes. This overlay is called the opercula (lid). The insula influences the motor and sensory functions of the intestines and is considered to be the link between cognitive and emotional elements in pain processing. It is also involved in processes such as taste and physical self-awareness.

1. Glossary

Confabulation

Confabulation refers to a memory or explanation that the person concerned is completely convinced is true, but which is objectively false. There is no conscious intent to deceive behind this. The cause is usually medical, such as damage to the orbitofrontal or other frontal brain areas, amnestic syndrome (e.g., Korsakoff's syndrome), traumatic brain injury, or dementia.

1. Glossary

Operculum

Cortical areas of the frontal, temporal, and parietal lobes at the lateral sulcus. The operculum covers the insular cortex.

1. Glossary

Parietal lobe

The parietal lobe is one of the four large lobes of the cerebral cortex. It is located behind the frontal lobe and above the occipital lobe. Somatosensory processes take place in its anterior region, while sensory information is integrated in its posterior region, enabling the handling of objects and spatial orientation. In addition, the parietal lobe is involved in attention, the recognition of body parts and objects, as well as linguistic and mathematical abilities. 

1. Glossary

Premotor cortex

Part of the motor cortex in the frontal lobe. It is connected to the primary motor cortex and numerous other brain regions and is involved in the planning, preparation, and coordination of complex, voluntary movements. Examples of its functions include reaching for an object or the sequence of movements involved in targeted actions.

1. Glossary

Primary motor cortex

An area of the frontal lobe in the anterior wall of the central sulcus. It is considered to be the higher-level control unit responsible for voluntary and fine motor skills. This is where the cell bodies of the central motor neurons are located, whose axons primarily extend to the spinal cord (via the corticospinal tract). Only in the primary motor cortex do Betz giant cells occur, which are particularly large motor neurons whose axons extend directly to the motor neurons in the anterior horn of the spinal cord without prior synaptic switching.