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- Glossary
Huntington's disease
Huntington's disease is a progressive and fatal hereditary disease that manifests itself in the brain. It is characterized by dyskinesia, dementia, and behavioral and psychological changes. To date, there is no cure, although scientists have a relatively good understanding of its molecular causes. The Huntington's gene of those affected contains up to 200 copies of a specific base triplet (group of three bases). This causes the cells to produce a defective protein, which primarily forms deposits in the striatum of the brain. This leads to degeneration of the neurons in the basal ganglia and the cortex.
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- Glossary
Ventrolateral nuclei
The lower lateral nucleus group of the thalamus is responsible for motor function (movement). It receives inputs from the cerebellum and basal ganglia and has outputs to motor and premotor areas of the cerebral cortex.
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- Glossary
Subthalamic nucleus
Although the subthalamic nucleus is a nucleus of the subthalamus in the diencephalon, it is functionally closely involved in the motor control of the basal ganglia. Damage to this nucleus can lead to temporary, uncontrolled, jerky movements of the extremities – known as ballism.
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- Topic
Structure and Function
Deep within the brain, wondrous things happen
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- Glossary
Parkinson's disease
Parkinson's disease is one of the most common neurological disorders, caused by the death of dopamine-producing neurons in the substantia nigra, leading to a neurotransmitter imbalance in the basal ganglia. Symptoms usually begin late in life with mild tremors (resting tremor), increasing stiffness of the limbs, and slowed voluntary movements (bradykinesia). Later, postural instability, balance disorders, and difficulty walking occur. Other typical features include rigid facial expressions (hypomimia), a shuffling gait, and muscle stiffness (rigor). The disease is incurable, but its symptoms can be treated with medication (e.g., L-dopa, dopamine agonists) or surgery involving deep brain stimulation (brain pacemaker).
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- Glossary
Nonspecific Thalamus
The "non-specific" thalamic nuclei, which have only a few connections to the cortex that are not limited to a specific area, are collectively referred to as the nonspecific thalamus and sometimes truncothalamus. It receives inputs from the reticular formation, the basal ganglia, and the cerebellum. Efferences go to most of the other thalamic nuclei.
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- Glossary
Subthalamus
The subthalamus is an area of the diencephalon located ventrally below the thalamus. It includes the subthalamic nucleus, which functionally belongs to the basal ganglia network. The subthalamus plays an important role in the regulation and inhibition of movement sequences and in impulse control.
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- Glossary
Subthalamic nucleus
Although the subthalamic nucleus is a nucleus of the subthalamus in the diencephalon, it is functionally closely integrated into the motor control of the basal ganglia. It plays a role in impulse control, movement control, and inhibition of unwanted movements. Damage to this nucleus can lead to temporary, uncontrolled, jerky movements of the extremities – known as ballism. Doctors have already achieved successful treatment outcomes in both obsessive-compulsive disorder and Parkinson's disease by artificially stimulating this region with a neuroimplant.
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- Glossary
Cerebrum
The cerebrum comprises the cerebral cortex (gray matter), the nerve fibers (white matter), and the basal ganglia. It is the largest part of the brain. The cortex can be divided into four cortical areas: the temporal lobe, frontal lobe, occipital lobe, and parietal lobe.Its functions include the coordination of perception, motivation, learning, and thinking.
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- Grundlagen
- Anatomy
The Limbic System
The limbic system does not solely control our emotional life. It also has other functions.
22.12.2023
